Publications

Preprint

Mechanism of Phosphoinositide Regulation of Lysosomal pH via Inhibition of CLC-7

J. K. Hilton, Y. Lin, E. Sefah, J. C. Deme, J. L. Parker, M. J. Langton, M. Grabe, S. Lea, S. Newstead, and J. A Mindell*, BioRxiv, 2025

Speciation and Luminescence of a Binuclear Lanthanide Complex Bearing an Aminophenolate Chromophore

V. R. M. Nielsen, C. H. Simms, D. Kovacs, M. F. Allen, M. J. Langton, S. Faulkner*, and T. J. Sørensen*, Chem. Eur. J., 2025, 31, e02305

Organic functionality in responsive paramagnetic nanostructures

A. M. Duncan, C. M. Ellis, J. P. Smith, L. Leutloff, M. J. Langton, and J. J. Davis*, Front. Chem., 2025, 13, 1605538

Responsive anion transport with a Hamilton receptor-based anionophore controlled by photo-activation and host-guest competitive inhibition

(Featured in the Chem. Sci. 15th Anniversary: Chemical Science Leading Investigators collection)

M. Ahmad, A. Docker, and M. J. Langton*, Chem. Sci., 2025, 16, 13715-13722

Ion transport across biological membranes

R. S. Bon* and M. J. Langton*, Curr. Op. Chem. Bio., 2025, 87, 102606

Chloride Selective, Non-protonophoric Ion Transport with Macrocyclic Halogen Bonding Anionophores

M. Flerin, F. Duarte*, and M. J. Langton*, Chem. Eur. J., 2025, 31, e202502033

Binuclear lanthanide complexes as magnetic resonance and optical imaging probes for redox sensing

C. H. Simms, D. Kovacs, L. Hacker, E. T. Sarson, D. Sokolova, K. E. Christensen, A. Khrapichev, L. Martin, K. Vincent, S. J. Conway, E. M. Hammond*, M. J. Langton*, and S. Faulkner*, Chem. Eur. J., 2025, 31, e202404748

ON-OFF nanopores for optical control of transmembrane ionic communication

X. Wang, A. Kerckhoffs, J. Riexinger, M. Cornall, M. J. Langton*, H. Bayley*, and Y. Qing*, Nat. Nanotechnol., 2025, 20, 432-440

Transmembrane Delivery of an Aryl Azopyrazole Photo-switchable Ion Transporter Relay

("Hot" paper)

E. Grählert, and  M. J. Langton*, Angew. Chem. Int. Ed., 2025, 64, e202421580

Off–On Photo- and Redox-Triggered Anion Transport Using an Indole-Based Hydrogen Bond Switch

M. Ahmad, A. Muir, and M. J. Langton*, ACS Omega, 2024, 9, 45572–45580

Stimuli-responsive anion transport utilising caged hydrazone-based anionophores

M. Ahmad, M. Flerin, H. M. Tay, A. L. Thompson,  F. Duarte*, and M. J. Langton*, Nanoscale, 2024, 16, 21545-21553

Transient Photoactivation of Anionophores by Using Redshifted Fast-Relaxing Azobenzenes

A. Kerckhoffs, M. Ahmad, and M. J. Langton*, Chem. Eur. J., 2024, 30, e202402382

Ion carrier modulated MRI contrast

A. M. Duncan, C. M. Ellis, H. Levingston, A. Kerckhoffs, F. E. Mozes, M. J. Langton, and J. J. Davis*, Chem. Sci., 2024, 15, 13937-13941

Length dependent reversible off-on activation of photo- switchable relay anion transporters

(Hot article and featured in Chem. Commun. 60th anniversary collection)

T. G. Johnson, A. Sadeghi-Kelishadi, M. J. Langton*, Chem. Commun., 2024, 60, 7160-7163

Photoswitchable Luminescent Lanthanide Complexes Controlled and Interrogated by Four Orthogonal Wavelengths of Light

C. Simms, V. R. M. Nielsen, T. J. Sørensen, S. Faulkner*, and M. J. Langton*, Phys. Chem. Chem. Phys., 2024, 26, 18683-18691

Responsive Anionophores with AND Logic Multi-Stimuli Activation

("Hot" paper)

M. Ahmad, T. G. Johnson, M. Flerin, F. Duarte, and M. J. Langton*, Angew. Chem. Int. Ed., 2024, 63, e202403314

Coupling Photoresponsive Transmembrane Ion Transport with Transition Metal Catalysis

X. Chao^†, T. G. Johnson^†, M. Temian, A. Docker, A. L. D. Wallabregue, A. Scott, S. J. Conway, and M. J. Langton*, J. Am. Chem. Soc., 2024, 146, 4351-4356

^†These authors contributed equally.

Molecular Machines for the Control of Transmembrane Transport

T. G. Johnson and M. J. Langton*, J. Am. Chem. Soc., 2023, 50, 27167-27184

Exploiting the Catenane Mechanical Bond Effect for Selective Halide Anion Transmembrane Transport

H. M. Tay, T. G. Johnson, A. Docker, M. J. Langton*, and P. D. Beer*, Angew. Chem. Int. Ed., 2023, 62, e202312745

Inter-vesicle Signal Transduction Using a Photo-responsive Zinc Ionophore

("Hot" paper)

S. A. Gartland, T. G. Johnson, E. Walkley, and M. J. Langton*, Angew. Chem. Int. Ed., 2023, 62, e202309080

Photo- and Redox-regulated Transmembrane Ion Transporters

M. Ahmad, S. A. Gartland, and M. J. Langton*, Angew. Chem. Int. Ed., 2023, 62, e202308842

Transmembrane Anion Transport Mediated by Sigma-Hole Interactions

A. Docker* and M. J. Langton*, Trends Chem., 2023, 5, 792-794

Halogen Bonding Relay and Mobile Anion Transporters with Kinetically Controlled Chloride Selectivity

T. G. Johnson, A. Docker, A. Sadeghi-Kelishadi, and M. J. Langton*, Chem. Sci., 2023, 14, 5006-5013

Multistate Redox-Switchable Ion Transport Using Chalcogen-Bonding Anionophores

A. Docker, T. G. Johnson, H. Kuhn, Z. Zhang, and M. J. Langton*, J. Am. Chem. Soc., 2023, 145, 2661-2668

Photo-switchable Anion Binding and Catalysis with a Visible Light Responsive Halogen Bonding Receptor

("Hot" Article, emerging investigator collection)

A. Kerckhoffs, I. Moss, and M. J. Langton*, Chem. Commun., 2023, 59, 51-54

Fast Relaxing Red and Near-IR Switchable Azobenzenes with Chalcogen and Halogen Substituents: Periodic Trends, Tunable Thermal Half-lives and Chalcogen Bonding

("Hot" Article and included in the Chemical Science 2022 most popular organic chemistry collection)

A. Kerckhoffs, K. E. Christensen, and M. J. Langton*, Chem. Sci., 2022, 13, 11551-11559

Controlling Transmembrane Ion Transport via Photo-Regulated Carrier Mobility

("Hot" Article)

L. E. Bickerton and M. J. Langton*, Chem. Sci., 2022, 13, 9531-9536

A Photo-responsive Transmembrane Anion Transporter Relay

T. G. Johnson, A. Sadeghi-Kelishadi, and M. J. Langton*, J. Am. Chem. Soc., 2022, 114, 10455-10461

Red-shifted Tetra-ortho-halo-azobenzenes for Photo-regulated Transmembrane Anion Transport

(Highlighted in Synfacts)

A. Kerckhoffs, Z. Bo, S. E. Penty, F. Duarte*, and M. J. Langton*, Org. Biomol. Chem., 2021, 12, 11252-11274

Supramolecular Chemistry in Lipid Bilayer Membranes

L. E. Bickerton^†, T. G. Johnson^†, A. Kerckhoffs^†, and M. J. Langton*, Chem. Sci., 2021, 12, 11252-11274

^†These authors contributed equally.

Halogen Bonding Tetraphenylethene Anion Receptors: Anion-induced Emissive Aggregates and Photoswitchable Recognition

A. Docker^†, X. Shang^†, D. Yuan, H. Kuhn, Z. Zhang, J. J. Davis, P. D. Beer*, and M. J. Langton*, Angew. Chem. Int. Ed., 2021, 23, 19442-19450

^†These authors contributed equally.

Highly Active Halogen Bonding and Chalcogen Bonding Chloride Transporters with Non-Protonophoric Activity

(Invited contribution to a special edition on "Non-covalent interactions")

L. E. Bickerton^†, A. Docker^†, A. J. Sterling, H. Kuhn, F. Duarte*, P. D. Beer*, and M. J. Langton*, Chem. Eur. J., 2021, 27, 11738-11745

^†These authors contributed equally.

Engineering of Stimuli-responsive Lipid-bilayer Membranes using Supramolecular Systems

M. J. Langton*, Nat. Rev. Chem., 2021, 5, 46-61

Triggered Release from Lipid Bilayer Vesicles by an Artificial Transmembrane Signal Transduction System

(Featured in "Chemical and Engineering News")

M. J. Langton*, L. M. Scriven, N. H. Williams, and C. A. Hunter, J. Am. Chem. Soc., 2017, 139, 15768-15773

Recognition-controlled Membrane Translocation for Signal Transduction across Lipid Bilayers

M. J. Langton, N. H. Williams*, and C. A. Hunter*, J. Am. Chem. Soc., 2017, 139, 6461-6466

Controlled Membrane Translocation Provides a Mechanism for Signal Transduction and Amplification

(Featured in News and Views: Nat. Chem., 2019, 9, 406-407, and the Nature Chemistry editorial 'Sending a message to the other side' Nat. Chem., 2017, 9, 403)

M. J. Langton, F. Keymeulen, M. Ciaccia, N. H. Williams*, and C. A. Hunter*, Nat. Chem., 2017, 9, 426-430

Active-metal Template Synthesis of a Halogen Bonding Rotaxane for Anion Recognition

(Highlighted in Synfacts, 2016, 12, 257)

M. J. Langton, Y. Xiong, and P. D. Beer*, Chem. Eur. J., 2016, 21, 18910-18914

Iodide Recognition and Sensing in Water by a Halogen Bonding Ruthenium(II)-based Rotaxane

("Hot paper")

M. J. Langton, I. Marques, S. W. Robinson, V. Félix, and P. D. Beer*, Chem. Eur. J., 2016, 22, 185-192

Anion Recognition in Water: Recent Advances from a Supramolecular and Macromolecular Perspective

M. J. Langton, C. J. Serpell, and P. D. Beer*, Angew. Chem. Int. Ed., 2016, 55, 1974-1987

Anion, Cation and Ion-pair Recognition by Macrocyclic and Interlocked Host Systems.

In Macrocyclic and Supramolecular Chemistry: How Izatt-Christensen Award Winners Shaped the Field; P. D. Beer and M. J. Langton, 2015, John Wiley & Sonts, Ltd., Chichester, UK.

Chloride-Anion-Templated Synthesis of a Strapped-Porphyrin-Containing Catenane Host System

(Designated a "Hot paper" and featured in Chemistry Views)

A. Brown, M. J. Langton, N. L. Kilah, A. L. Thompson, and P. D. Beer*, Chem. Eur. J., 2015, 21, 17664-17675

Halogen Bonding in Supramolecular Chemistry

L. C. Gilday, S. W. Robinson, T. A. Barendt, M. J. Langton, B. R. Mullaney, and P. D. Beer*, Chem. Rev., 2015, 115, 7118-7195

Anion Recognition in Water by a Rotaxane Containing a Secondary Rim Functionalised Cyclodextrin Stoppered Axle

M. Rezanka, M. J. Langton, and P. D. Beer*, Chem. Commun., 2015, 51, 4499-4502

Halogen Bonding in Water Results in Enhanced Anion Recognition in Acyclic and Rotaxane Hosts

(Selected for journal front cover pictures Dec. 2014, featured in News and Views: Nat. Chem., 2014, 6, 1029-1031)

M. J. Langton, S. W. Robinson, I. Marques, V. Félix and P. D. Beer*, Nat. Chem., 2014, 6, 1039-1043

Nitrite-Templated Synthesis of Lanthanide-Containing [2]Rotaxanes for Anion Sensing

M. J. Langton, O. A. Blackburn, T. Lang, S. Faulkner, and P. D. Beer*, Angew. Chem. Int. Ed., 2014, 53, 111463-11466

Nitrate Anion Templated Synthesis of a [2]Catenane for Nitrate Recognition in Organic-Aqueous Solvent Media

M. J. Langton and P. D. Beer*, Chem. Commun., 2014, 50, 8124-8127

Rotaxane and Catenane Host Structures for Sensing Charged Guest Species

M. J. Langton and P. D. Beer*, Acc. Chem. Res., 2014, 47, 1935-1949

Nitrate Anion Templated Assembly of a [2]Rotaxane for Selective Nitrate Recognition in Aqueous Solvent Mixtures

M. J. Langton, L. C. Duckworth, and P. D. Beer*, Chem. Commun., 2013, 49, 8608-8610

Lanthanide-cation Templated Synthesis of Rotaxanes

F. Zapata, O. Blackburn, M. J. Langton, S. Faulkner, and P. D. Beer*, Chem. Commun., 2013, 49, 8157-8159

Sulfate-selective Binding and Sensing of a Fluorescent [3]Rotaxane Host System

M. J. Langton and P. D. Beer*, Chem. Eur. J., 2012, 18, 14406-14412

Template-directed Synthesis of π- conjugated Porphyrin [2]rotaxanes and a [4]catenane based on a six-porphyrin nanoring

(Selected for journal cover)

M. J. Langton, J. D. Matichak, A. L. Thompson, and H. L. Anderson*, Chem. Sci., 2011, 2, 1897-1901